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摘要
摘要
Cellular and Molecular Biology of Cancer is intended to provide a relatively brief yet comprehensive overview of cancer biology that covers the current status of both research and treatment. For the student or new researcher the breadth of cancer research can appear daunting yet a broad understanding is essential for translation of laboratory findings into the clinic. Each topic is reviewed authoritatively by an expert in the field and the bibliographies provided allow rapid access to the relevant current literature. The fourth edition of this popular text covers topics extending from the molecular alterations found in cancer cells and their causes to the current range of approaches to treatment. This is intended as a textbook for both undergraduate and postgraduate use and as an introduction for clinicians and scientists new to the field. Since the third edition in 1996 there has been unprecedented progress in cancer research and the extensive revision and many new chapters in the new edition reflect this.
评论 (1)
Doody 图书评论
This book is truly what its title says it is -- a highly comprehensive, up-to-date guide to the molecular basis of carcinogenesis. It is divided into concise chapters that direct the reader through the world of cancer, from the very basics to up-to-date descriptions of signal transduction pathways. Additionally, a number of chapters describe treatments for cancer, including current immunological and monoclonal antibody-based therapies. The book was written for students, clinicians, and scientists new to the field of molecular carcinogenesis. I feel that this book truly meets these expectations and in many cases provides extra knowledge. Each chapter is written by experts in the field. The book is well illustrated with many helpful, easy to follow figures and tables. The references are appropriate and up-to-date. Additionally, this book has a very extensive glossary of terms commonly used in cancer and molecular carcinogenesis. I feel the third edition of this book is entirely necessary (the previous edition was published in 1990) as the fields of molecular biology of cancer and cancer treatments are continuously evolving and it is essential that anyone new to these fields has access to the most current concepts. I would definitely recommend this book to anyone starting out in the fields of oncology and cancer research. Ruth O'Regan, MD(Northwestern University Medical School). Copyright 2001, Doody Publishing
目录
Contributors | p. xv |
1 What is cancer? | p. 1 |
2 The causes of cancer | p. 25 |
3 Inherited susceptibility to cancer | p. 45 |
4 DNA repair and cancer | p. 61 |
5 Epigenetic events in cancer | p. 78 |
6 Molecular cytogenetics of cancer | p. 95 |
7 Oncogenes | p. 117 |
8 Tumour suppressor genes | p. 135 |
9 The cancer cell cycle | p. 156 |
10 Cellular immortalization and telomerase activation in cancer | p. 170 |
11 Growth factors and their signalling pathways in cancer | p. 186 |
12 Apoptosis: molecular physiology and significance for cancer therapeutics | p. 210 |
13 Mechanisms of viral carcinogenesis | p. 229 |
14 Cytokines and cancer | p. 242 |
15 Hormones and cancer | p. 257 |
16 The spread of tumours | p. 278 |
17 Tumour angiogenesis | p. 289 |
18 Stem cells, haemopoiesis, and leukaemia | p. 305 |
19 Animal models of cancer | p. 317 |
20 The immunology of cancer | p. 337 |
21 The molecular pathology of cancer | p. 356 |
22 From transcriptome to proteome | p. 369 |
23 Local treatment of cancer | p. 390 |
24 Chemotherapy | p. 399 |
25 Radiotherapy and molecular radiotherapy | p. 414 |
26 Monoclonal antibodies and therapy | p. 428 |
27 Immunotherapy of cancer | p. 443 |
28 Cancer gene therapy | p. 458 |
29 Screening | p. 480 |
30 Conclusions and prospects | p. 503 |
Index | p. 506 |