An inherited disorder primarily affecting the lungs and digestive system, cystic fibrosis currently has no cure and generally proves fatal. Even patients fortunate enough to receive a lung transplant have only a 50/50 five-year survival rate. This ABC News program follows four patients at different stages of the disease, including a 39-year-old in urgent need of a transplant. The efforts of the doctors and scientists of Johns Hopkins Medicine to fight CF with promising applications of gene therapy are also presented.